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The Enzyme Optimization Decision for Assay Developers: De novo or OTS tailoring?
Assay developers are often faced with two paths to optimize reagents and enzyme performance: engineering new reagents or using an off-the-shelf version and tailoring its specifications. Which is the better choice? Our team specializes in optimizing enzymes and reagents for…
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Turning Catalog Reagents into Custom Reagents – What You Need to Know
Development teams building diagnostic, sequencing, and point-of-care (POC) platforms often start a new product cycle with off-the-shelf reagents. These are typically catalog items that are widely available, not just to developers, but also to research scientists and laboratories, making them…
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When Catalog Enzymes Stop Being the Answer Custom Enzymes Are
Molecular diagnostic platforms, sequencing technologies, and point-of-care systems are becoming increasingly specialized. These devices often feature microfluidic cartridges, ultra-low reaction volumes, rapid cycling protocols, and simplified workflows that minimize sample cleanup, as well as lyophilized/ambient stable formats. With increasing differentiation,…
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Overcoming Challenges in CRISPR – Cas Applications
Arriving at the perfect CRISPR system and how to troubleshoot for therapeutic development. Over the past decade, CRISPR systems have revolutionized both genome editing and molecular diagnostics. This versatile technology, capable of targeting a variety of genetic sequences, has steadily…
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Lyophilized Reagent Performance: Improving Diagnostic Consistency
How Lyophilized Reagents Improve Sensitivity in Diagnostic Assays In diagnostics, sensitivity often comes down to one significant criterion: consistency. Even with a solid assay design, performance can drift because reagents behave differently over time, or across storage conditions. Lyophilization, the…
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Reagent Lyophilization Scale-up: From R&D to Manufacturing
From Bench to Production: Streamlining Reagent Lyophilization Manufacturing Reagent lyophilization scale-up from research to manufacturing can be challenging, even for experienced teams. The process involves balancing formulation science, engineering controls, documentation, and scale-up logistics while simultaneously keeping timelines realistic, costs…
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